| Entry |
|
|---|
| Name |
Benzbromarone (JP18/USAN/INN);
Uroleap (TN) |
|---|
| Formula |
C17H12Br2O3
|
|---|
| Exact mass |
421.9153
|
|---|
| Mol weight |
424.08
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Musculo-skeletal system agent
DG02042 Uricosurics
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
Unclassified
DG03334 Urate transporter inhibitor
|
|---|
| Remark |
| Therapeutic category: | 3949 |
|
|---|
| Efficacy |
Gout suppressant, Uricosuric |
|---|
| Target |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M04 ANTIGOUT PREPARATIONS
M04A ANTIGOUT PREPARATIONS
M04AB Preparations increasing uric acid excretion
M04AB03 Benzbromarone
D01056 Benzbromarone (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
394 Gout preparations
3949 Others
D01056 Benzbromarone (JP18/USAN/INN)
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG02042 Uricosurics
D01056 Benzbromarone
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D01056 Benzbromarone
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
D01056 Benzbromarone
Unclassified
DG03334 Urate transporter inhibitor
D01056 Benzbromarone
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC22
SLC22A12 (URAT1)
D01056 Benzbromarone (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01056 Benzbromarone
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01056
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 C8x C 15.0500 -18.8300
2 C8x C 15.0500 -20.2300
3 C8x C 16.2624 -20.9300
4 C8y C 17.4749 -20.2300
5 C8y C 17.4749 -18.8300
6 C8x C 16.2624 -18.1300
7 O2x O 18.8064 -20.6626
8 C8y C 19.6293 -19.5300
9 C8y C 18.8064 -18.3974
10 C1b C 21.0000 -19.5300
11 C1a C 21.7000 -20.7424
12 C5a C 19.2376 -17.0706
13 C8y C 20.6169 -16.7775
14 C8x C 21.5795 -17.8469
15 C8y C 22.9490 -17.5561
16 C8y C 23.3818 -16.2247
17 C8y C 22.4193 -15.1553
18 C8x C 21.0498 -15.4461
19 X Br 22.8399 -13.8609
20 O1a O 24.7464 -15.9350
21 X Br 23.8974 -18.6098
22 O5a O 18.3111 -16.0415
BOND 24
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 2
10 5 9 1
11 8 10 1
12 10 11 1
13 9 12 1
14 12 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 17 19 1
22 16 20 1
23 15 21 1
24 12 22 2
|
|---|
